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PULMONARY VENTILATION AND DIFFUSION IN SHOCK
BOSTON UNIV MA
Injection of endotoxin in dogs resulted in a sudden fall in compliance and a rise in resistance to airflow immediately following injection. These changes were transitory and less constant in animals which were heparinized. Further studies of pulmonary diffusion in dogs confirmed the fall in the diffusion capacity for carbon monoxide DLCO and in lung capillary blood volume Vc during both acute and irreversible shock. The fall in DLCO was always proportional to the volume of red blood cells in the lung capillaries Vrbc. The fall in Vc was not related to the duration of the anesthesia nor to the retransfusion of blood. Control studies were carried out as a preliminary to the evaluation of patients in shock.
Annual rept. for 1 Jun 1963-31 May 1964
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