DID YOU KNOW? DTIC has over 3.5 million final reports on DoD funded research, development, test, and evaluation activities available to our registered users. Click HERE
to register or log in.
IMMUNOLOGICAL ASPECTS OF EXPERIMENTAL TOXOPLASMOSIS.
KEIO UNIV TOKYO (JAPAN) SCHOOL OF MEDICINE
Mice which survived a prior infection with a low virulent toxoplasmas tolerated a challenge infection with a highly virulent strain. Of 35 mice which survived the challenge infection with RH, the brains of 22 of these mice were shown to have living parasites. Vaccinations with heat-killed toxoplasmas alone or in incomplete or complete adjuvants seemed to have no effect in increasing the protection of the mice against a challenge RH infection. Vaccination with sonic disrupted parasites also failed to protect mice against RH challenge. Passive immunization with anti-toxoplasma sera obtained from infected rabbits and pigs demonstrated very little effects in prolongation of the survival period of infected mice. Intraperitoneal transference of the immune cells showed no effect in prolongation of the survival time of infected mice. Development of cellular immunity to some extent, however, was indicated by the experiments employing diffusion chambers implanted in the peritoneal cavity of mice. The role of antibody in the formation of cyst of Toxoplasma was investigated. The anti-metabolite 6-mercaptopurine was inoculated into infected mice in order to inhibit the normal immune response of mice to the parasite. The results tended to indicate that antibody was not an essential prerequisite to cyst formation. Author
Final rept. 28 May 64-27 May 65,