Accession Number:

AD0450109

Title:

ANTIGENICITY OF IRRADIATED PASTEURELLA TULARENSIS VACCINES IN MICE

Personal Author(s):

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Report Date:

1964-08-01

Abstract:

Viable attenuated tularemia vaccines have been shown to be effective in immunizing mice and other animals against challenge with highly virulent Pasteurella tularensis. Preparations made nonviable by the action of heat or chemicals, however, induce little or no resistance to challenge with even small numbers of virulent organisms. In these studies, vaccines rendered nonviable by the action of ionizing radiation produced levels of immunity such that 20 to 30 of immunized mice survived intraperitoneal challenge with moderate doses of the highly virulent SCHU S4 strain of P. tularensis. Both x- and electron beam- irradiation were effective in preparing the vaccine, which contained from 1.4 x 10 to the 8th power to 4.0 x 10 to the 9th power nonviable organisms per milliliter.

Descriptive Note:

Technical Manuscript

Supplementary Note:

DOI: 10.21236/AD0450109

Pages:

0010

Descriptors:

Identifiers:

Subject Categories:

File Size:

0.36MB

View The Document