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INFLUENCE OF LOW AMBIENT TEMPERATURE ON RESIST ANCE OF MICE TO EXPERIMENTAL COXSACKIE VIRUS INFECTION,
UTAH UNIV SALT LAKE CITY COLL OF MEDICINE
Adult albino mice were challenged intraperi toneally with Type B-1 Coxsackie virus under conditions of acclimatization and nonacclimati zation to 1 C. The results show that exposure of unacclimatized mice to 2 C results in lowered host resistance but that specific immunization is effective in protection under these conditions. Mice acclimatized to 2 C for 40 days have in creased resistance to challenge that is independ ent of specific immunization procedures. The mechanisms involved in protection under these circumstances remain to be explored. Author