MASSACHUSETTS INST OF TECH CAMBRIDGE METALS PROCESSING LAB
Milan U. Italy. CHOLESTEROL AND FA TY ACID BIO YNTHESIS IN BRAI . Annual technical rept., 1 Aug 61-31 July 62, b S. Garattini. 31 J ULY , P. INCL. ILLUS. ABLES. Con ract DA 91-591-EUC-1836 U cla ified report DE CRIP OR Brain, Cholesterol, Fatty acids, Serum, Liver, Laboratory animal , Aor a, Rats, Metabolism, Biosynthesis. Iden ifi rs Propylthiouracil. P ROPYLTHIOURACIL, GIVEN I T DI T OF OT ERS FROM TH E D OF PREGNANCY, PRODUCES IN LITTERS A STR NG ELEVATION OF SERUM C OLESTEROL AND A MODERATE INCREASE OF LIVER AND AORTA CHOLESTEROL. The cholesterol synthesis in brain i very low when 2-C14 -mevalonolactone is used as substrate but con iderably i creases when the potassium salt of 2-C14-mevalonic acid is incubat d with the slice or the homogenate . M EVALONICKINASE IS PRESENT IN BRAIN ALTHOUGH IN CONCENTRATIO per unit of weight lower than that pres nt in liver. In adult br in when cholesterol synthesis does not occur mevalonic kinase is still active. Aut or A -294 4329N C HOLESTEROL AND FA TY ACID BIOSYNTHESIS IN BRAIN. Effect of propylthiouracil on tissue lipids of new born rats differential incorporation of K-mevalonate an mev lonolactone synthesis and activ tion of mevalonic acid i rat liv r and brain.