DID YOU KNOW? DTIC has over 3.5 million final reports on DoD funded research, development, test, and evaluation activities available to our registered users. Click HERE
to register or log in.
Final Progress Report on Contract No. DA18-108-405-CML-264 (Colorado School of Medicine)
COLORADO UNIV MEDICAL CENTER DENVER
Studies were made of the effect of administration of atropine in normal persons on blood composition, renal function and salivary flow. The effect of anticholinesterase agents on the rate of passage of Na24 across the blood brain barrier were completed. Data indicated that neither physostigmine or atropine altered significantly the rate of passage of Na24 across the blood brain barrier in rats and rabbits over the fourhour period studied. Measurements were made of the changes in plasma and extracellular volume produced by injection of physostigmine and acetylcholine and of the blocking effect of atropine. In vitro studies were done on changes in rate of transfer of radio-active isotopes across the red cell membrane after inhibition of red cell cholinesterase activity by anticholinesterase agents. This also included studies of the effects of blood storage on the red cell and plasma cholinesterase activity. Preliminary reports of the results were submitted. Investigations were also made of the changes in liver blood flow and BSP clearance produced by injection of physostigmine and acetylcholine in the unanesthetized dog. Additional experiments were performed in which atropine was administered prior to injection of physostigmine.
EXTRACELLULAR VOLUME PRODUCED BY INJECTION OF PHYSOSTIGMINE AND ACETYLCHOLINE AND OF THE BLOCKING EFFECT OF ATROPINE, AND STUDY OF CHANGES OF THESE DRUGS IN LIVER BLOOD FLOW AND BSP CLEARANCE DOI: 10.21236/AD0288692
Approved for public release; distribution is unlimited.