Accession Number:

AD0272379

Title:

INCREASED CORTICOSTEROID BINDING (TRANSCORTIN) ACTIVITY IN ADRENALECTOMIZED AND HYPOPHYSECTOMIZED RATS

Personal Author(s):

Corporate Author:

ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Report Date:

1962-01-15

Abstract:

Equilibrium dialysis experiments with pooled sera of rats demonstrate that the binding activity of the specific corticosteroid-binding protein transcortin is higher in adrenalectomized and hypophysectomized animals than in normal controls. Rat serum at both 4 C and 37 C has a higher binding affinity for corticosterone than for cortisol, whereas in human serum at 4 C, cortisol appears to be bound more fir ly than corticosterone. The transcortin systems of man and rat, therefore, show distinct differences. Author

Pages:

0008

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0.00MB

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