Accession Number:

AD0260387

Title:

RESIDUAL RADIATION INJURY EVIDENCED BY IMPAIRED REGROWTH OF REALIMENTED HYPOCALORICALLY REARED RATES

Personal Author(s):

Corporate Author:

NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Report Date:

1961-06-21

Abstract:

Hypocalorically reared rats were subjected to single exposures of X ray ranging from 400 to 700 rad, or to repetitive exposures of 200 rad in 4 doses spaced 1 wk apart total 800 rad. They were allowed to recover for a minimum of 7 wk and a maximum of 6 mo following the last exposure and then returned to an adequate caloric intake. Realimentation of the irradiated populations resulted in reduced regrowth when compared to non-irradiated realimented rats of the sameAGE. The reduction in regrowth persisted regardless of radiation exposure patterns, realimentation patterns or the recovery periods here employed. Paired-feeding demonstrated that the regrowth reduction is primarily one of reduced nutrient utilization. G.I. tract shielding showed that injury to the intestinal region with impaired absorption is probably not the cause. It is concluded that the regrowth of the irradiated realimented rats is a generalized deficiency of nutrient utilization by the organs and tissues, perhaps mediated through the endocrines. Author

Pages:

0001

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0.00MB

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