A Hybrid Laser/Aerosol Method for the Synthesis of Porous Nanostructured Calcium Phosphate Materials for Bone Tissue Engineering Applications
ALABAMA UNIV IN BIRMINGHAM
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We present a new synthesis method based on laser generation and processing of aerosol particles that can produce calcium phosphate coatings in a porous nanostructured configuration. The process uses laser ablation of crystalline hydroxyapatite targets to produce a calcium phosphate aerosol comprising micro- and nanoparticles that are processed and deposited on metallic substrates under well-controlled temperature and ambient conditions, creating a microporous calcium phosphate network suitable for growth of biogenic calcium phosphate materials. Laser ablation is carried out using a KrF excimer laser at fluences between 0.4 Jcm2 and 2.8 Jcm2 and temperatures ranging from 500 deg C to 760 deg C. X-ray diffraction and scanning electron microscopy measurements on samples deposited above 750 deg C show that the obtained material is crystalline hydroxyapatite with good mechanical stability. Its microstructure features a porous framework of partially sintered microparticles surrounded by nanoparticulate material.
- Inorganic Chemistry
- Ceramics, Refractories and Glass
- Coatings, Colorants and Finishes