N-Isopropylacrylamide-Based Copolymers with Time-Dependent LCST for a Bioresorbable Carrier
ARIZONA STATE UNIV TEMPE DEPT OF BIOENGINEERING
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To develop a new class of in situ-forming, injectable, and biodegradable polymeric biomaterials based on time-dependent lower critical solution temperature LCST properties for localized delivery, copolymers of N-isopropylacrylamide NIPAAm, 2-hydroxyethyl methacryl lactate HEMA-lactate and acrylic acid AAc were prepared with varying mole ratios of monomers. The copolymers showed LCST and gelation properties below body temperature in 0.1 N PBS solution of pH 7.4. The LCST and gelation temperature of the copolymers decreased as the HEMA-lactate content of the copolymers was increased. The copolymers also showed time-dependent LCST and gelation properties in 0.1 N PBS solution of pH 7.4 owing to hydrolysis of HEMA-lactate. Hydrolysis of HEMA-lactate caused the polymers to be more hydrophilic, resulting in an increase in LCST and gelation temperature. All the polymers with about 6 mol AAc exhibited LCST and gelation temperature above body temperature after complete hydrolysis of HEMA-lactate.
- Polymer Chemistry