Accession Number:

ADP019726

Title:

N-Isopropylacrylamide-Based Copolymers with Time-Dependent LCST for a Bioresorbable Carrier

Descriptive Note:

Conference paper

Corporate Author:

ARIZONA STATE UNIV TEMPE DEPT OF BIOENGINEERING

Personal Author(s):

Report Date:

2005-01-01

Pagination or Media Count:

6.0

Abstract:

To develop a new class of in situ-forming, injectable, and biodegradable polymeric biomaterials based on time-dependent lower critical solution temperature LCST properties for localized delivery, copolymers of N-isopropylacrylamide NIPAAm, 2-hydroxyethyl methacryl lactate HEMA-lactate and acrylic acid AAc were prepared with varying mole ratios of monomers. The copolymers showed LCST and gelation properties below body temperature in 0.1 N PBS solution of pH 7.4. The LCST and gelation temperature of the copolymers decreased as the HEMA-lactate content of the copolymers was increased. The copolymers also showed time-dependent LCST and gelation properties in 0.1 N PBS solution of pH 7.4 owing to hydrolysis of HEMA-lactate. Hydrolysis of HEMA-lactate caused the polymers to be more hydrophilic, resulting in an increase in LCST and gelation temperature. All the polymers with about 6 mol AAc exhibited LCST and gelation temperature above body temperature after complete hydrolysis of HEMA-lactate.

Subject Categories:

  • Polymer Chemistry
  • Thermodynamics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE