Accession Number:

ADP013768

Title:

Wakening Substances: Caffeine (Substance eveillante: la cafeine)

Descriptive Note:

Corporate Author:

INSTITUT DE MEDECINE AEROSPATIALE DU SERVICE DE SANTE DES ARMEES CEDEX (FRANCE)

Report Date:

2002-11-01

Pagination or Media Count:

11.0

Abstract:

Caffeine is the most widely used psychostimulant, whose acceptance, tolerance and side effects are well known. The development of a slow released SRC formulation optimizes caffeine as a fatigue and sleep deprivation counter-measure. Due to its pharmacokinetic properties delayed T sub max and reduced C sub max, a single 300 mg SRC oral dose per day is effective to maintain alertness and performance, up to 45 hours in a total sleep deprivation situation. Compared to other psychostimulants like amphetamines or modafinil, slow released caffeine offers the best ratio effectivenesstolerance-acceptance. Therefore SRC potential use in the military is wider than these exotic drugs, and could benefit to military personnel submitted to sustained or continuous operations.

Subject Categories:

  • Biochemistry
  • Stress Physiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE