Accession Number:

ADP013612

Title:

A Highly Sensitive and Selective Surface-Enhanced Nanobiosensor

Descriptive Note:

Conference paper

Corporate Author:

NORTHWESTERN UNIV EVANSTON IL DEPT OF CHEMISTRY

Personal Author(s):

• Haes, Amanda J.
• Van Duyne, Richard P.

Report Date:

2002-04-05

Pagination or Media Count:

6.0

Abstract:

Nanosphere lithography NSL derived triangular Ag nanoparticles were used to create an extremely sensitive and specific optical biological and chemical nanosensor. Using simple UV-vis spectroscopy, biotinylated surface-confined Ag nanoparticles were used to detect streptavidin down to one picomolar concentrations. The system was tested for nonspecific binding interactions with bovine serum albumin and was found to display virtually no adverse results. The extremely sensitive and selective response of the Ag nanoparticle sensor indicates an exciting use for biological and chemical sensing.

Descriptors:

• *ANALYTICAL CHEMISTRY
• OPTICAL PROPERTIES
• PROTEINS
• LITHOGRAPHY
• ULTRAVIOLET SPECTROSCOPY
• SURFACE CHEMISTRY
• BIOLOGICAL DETECTION
• PLASMONS
• SILVER
• CHEMICAL DETECTION
• SERUM ALBUMIN
• NANOTECHNOLOGY

Subject Categories:

• Physical Chemistry
• Miscellaneous Detection and Detectors

Distribution Statement:

APPROVED FOR PUBLIC RELEASE