Binding Studies on Resins Imprinted with (S)-naproxen
COLLEGE OF WILLIAM AND MARY WILLIAMSBURG VA
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Resins were prepared in a free-radical polymerization of 4-vinylpyridine and ethylene glycol dimethacrylate in the presence of S--6-methoxy-alpha-methyl-2- naphtaleneacetic acid S-naproxen. Initially S-naproxen, the imprinted molecule template, was assembled with the monomer 4-vinylpyridine by non-covalent interactions. After the polymerization, stepwise removal of the template left binding sites that retain complementary specificity and affinity. Binding parameters including the maximum number of binding sites and dissociation constant were calculated from the amount of template removed using a two-site Scatchard equation. The results are typical of other systems reported in the literature.
- Polymer Chemistry