Accession Number:

ADP013608

Title:

Studies on the Process of Formation, Nature and Stability of Binding Sites in Molecularly Imprinted Polymers

Descriptive Note:

Conference paper

Corporate Author:

JOHANNES GUTENBERG UNIV MAINZ (GERMANY) INST FUR ANORGANISCHE CHEMIE UND ANALYTISHCHE CHEMIE

Report Date:

2002-04-05

Pagination or Media Count:

11.0

Abstract:

In Molecular Imprinting the nature of the templated binding sites and the mechanism of their formation are still poorly understood. For this reason our groups are carrying out fundamental studies concerning known imprinting protocols, with the primary aim of shedding light on the role of the template in the different steps of the polymerization, from the formation of primary chains to the build-up of the porous structure. In this paper we report our initial results concerning copolymers of methacrylic acid MAA and ethyleneglycol dimethacrylate EDMA and their formation in presence or absence of the templates 9-ethyladenine, ametryn or terbutylazine. Monitoring the monomer disappearance by H-1-NMR showed that the presence of templates such as 9-ethyladenine significantly retarded the polymerization but otherwise had minor influence on the relative reactivity of the monomers. The latter appeared in most cases to be stoichiometrically incorporated into the polymer. The signals arising from the template experienced little or no shift in the early stage of the polymerization, although pronounced broadening was observed. By delaying the addition of the template, it was observed that binding sites with high selectivity could be induced more than one hour after the gel point of the system had been passed. Finally, the results of post-polymerization curing on the dry and swollen state porosities and the recognition properties of terbutylazine imprinted polymers are reported. This treatment when preformed at temperatures between lOO-l2O degrees C, slightly enhanced the selectivity of the polymers, whereas at higher temperatures the polymers lost their molecular recognition properties. Swollen state porosity derived from inverse size exclusion chromatography ISEC revealed an interesting sharpening of the pore size distribution for the imprinted compared to the non-imprinted polymers.

Subject Categories:

  • Polymer Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE