Oligonucleofide Imprinting in Aqueous Environment
CALIFORNIA UNIV IRVINE DEPT OF CHEMISTRY
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The development of synthetic receptors that recognize nucleotide bases and their derivatives is an important area of research 1-3. Applications are envisioned in separation science, biosensors, drug therapy and genetic engineering. Previously in this laboratory, we have developed a molecularly imprinted synthetic receptor for 9-ethyladenine 9-EA. The network polymer has an affinity for adenine and its derivatives with an average association constant Ka of 75,000 M-1 in CHCl3.
- Polymer Chemistry