Accession Number:

ADP013429

Title:

O-Alkyl-O-Methylchlorformiminophenyl Phosphonates Delayed Neurotoxicity Risk Assessment. In Vitro and In Vivo Studies

Descriptive Note:

Corporate Author:

AKADEMIYA NAUK SSSR MOSCOW

Report Date:

2001-09-01

Pagination or Media Count:

9.0

Abstract:

In the present work we report an in vitro study of NTE and AchE inhibition by a series of model phenylphosphonates of the general formula ROC6H5POON-VVlCH3 PhP, the assessment of neuropathic potential for the investigated OPs using ratios kiNTEkiAChE and comparison the obtained results with the ratios of the median effective doses ED50 for hen brain NTE and AChE inhibition obtained in vivo.

Subject Categories:

  • Biochemistry
  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE