O-Alkyl-O-Methylchlorformiminophenyl Phosphonates Delayed Neurotoxicity Risk Assessment. In Vitro and In Vivo Studies
AKADEMIYA NAUK SSSR MOSCOW
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In the present work we report an in vitro study of NTE and AchE inhibition by a series of model phenylphosphonates of the general formula ROC6H5POON-VVlCH3 PhP, the assessment of neuropathic potential for the investigated OPs using ratios kiNTEkiAChE and comparison the obtained results with the ratios of the median effective doses ED50 for hen brain NTE and AChE inhibition obtained in vivo.
- Chemical, Biological and Radiological Warfare