Accession Number:

ADP013428

Title:

Blood Neuropathy Target Esterase as Biochemical Marker for Neuropathic Organophosphates Exposure

Descriptive Note:

Corporate Author:

AKADEMIYA NAUK SSSR MOSCOW

Personal Author(s):

• Makhaeva, Galina
• Sigolaeva, Larisa
• Zhuravleva, Lyudmila
• Eremenko, Arkady
• Kurochkin, Ilya

Report Date:

2001-09-01

Pagination or Media Count:

11.0

Abstract:

In the present work we report the results of studies of possibility of application of biosensor methods to the NTE activity analysis in whole blood as well the results of OPIDN modeling in experiments on animals with acute administration of the increasing doses neuropathic OP O, O-dipropyldichlorvinylphosphate PrDChVP and studying the correlation between NTE inhibition in brain and blood using spectrophotometric and biosensor methods.

Descriptors:

• *CHEMICAL AGENTS
• *ORGANOPHOSPHATES
• *ESTERASES
• USSR
• BRAIN
• TOXICITY
• EXPOSURE(PHYSIOLOGY)
• ACETYLCHOLINESTERASE
• BLOOD
• SPECTROPHOTOMETRY
• PERIPHERAL NEUROPATHY

Subject Categories:

• Biochemistry
• Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE