Accession Number:

ADP013402

Title:

High Dose Pralidoxime (PRX) Treatment Prolongs Time to Extubation (TTE) and Increases Mortality in Paraoxon (POX) Exposed Minipigs

Descriptive Note:

Corporate Author:

HEIDELBERG UNIV (GERMANY F R) PHARMAKOLOGISCHES INST

Report Date:

2001-09-01

Pagination or Media Count:

2.0

Abstract:

Organophosphates are inhibitors of serine hydrolases. Oximes are clinically available enzyme reactivators. To determine in vivo the effect of high dose PRX use on time-to-extubation TTE and mortality as compared to identical therapy without PRX. 12 anaesthetized minipigs were used. All pigs received iv-POX lmgkg BW over 50 minutes. Group one n 6 received conventional intensive care therapy as described previously J Appi Toxicol 18 293 - 298. Group two n 6 received in addition iv-PRX 10 g 300 mgkg BW. Before BASE-LINEBL, after POX application 50 min and then at 1,2,3,4,8 and 16 hours after POX AChE and BChE activities were measured. Statistics rank order test significance for p 0.05. In group one TTE was 7.2 - 4.4 h after last measurement. Mortality was 0. In group two TTE was 14.7 - 6.4 h after last measurement. Mortality was 46. Pralidoxime therapy has no beneficial effect and its use can not be recommended.

Subject Categories:

  • Toxicology
  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE