The Treatment of Intoxication with Selected Organophosphates and a Carbamate: Comparison of different Therapeutic Approaches
MILITARY MEDICAL ACADEMY HRADEC KRALOVE(CZECHOSLOVAKIA)
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The treatment of intoxications 2xLD5O with sarin, DDVP and pyridostigmine s.c. was studied in rats. The animals were s.c. injected with toxic chemicals and treated i.m. with atropine, atropine and obidoxime omitted for pyridostigmine, sodium bicarbonate i.p., atropine i.m. and sodium bicarbonate i.p.. The start of treatment was at the onset of convulsions. Acetyleholinesterase AChE activity and pH in thc blood different time intervals and AChE activity in the frontal cortex, basal ganglia, pontomedullar part and hippocampus were determined after death or 24 h. In intoxications with all compounds studied, rapid decrease of the blood AChE activity was observed. In the brain, AChE activity was decreased with the exception of pyridostigmine. Detected pH in the blood showed its decrease following intoxication. In sarin intoxication, the only atropine and obidoxime showed minimal therapeutic effect lO of survival. In case of DDVP, theraputic effect increased in following manner bicarbonate 8O lethality atropine 60 lethality atropine and bicarbonate 50 lethality atropine and obidoxime 30 lethality. Therapeutic efficacy in case of pyndostigmine was increased in the following manner bicarbonate 80 lethalityatropine 50 lethality atropine and bicarbonate 20 lethality. The results indicate that administration of bicarbonate improves the therapy of organophosphate and pyridostigmine intoxication.
- Chemical, Biological and Radiological Warfare