Studies on the Interaction of Water-Soluble Fullerols with BSA and the Effects of Metallic Ions
TAIYUAN UNIV OF TECHNOLOGY SHANXI (CHINA) COLL OF MATERIALS SCIENCE AND ENGINEERING
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The interaction of water-soluble C60 derived fullerols with bovine serum albumin BSA in physiological environment was studied in detail by the fluorescence method. Experiments showed that the interaction of fullerols with BAS is mainly in the manner of non-covalent hydrogen bond. Based on the measurements of fluorescence intensity, the apparent binding constant K and the binding site number n were obtained with K4OOO and n1, and the energy transfer efficiency in the reaction is 0.63. Besides, the effects of metallic ions such as Cu2, Fe3 and CrVI on the interaction of fullerols with BSA were investigated. It was found that the effects of the metallic ions are quite different from each other. Low concentrations of Cu2 can promote the interactions between fullerols and BSA, while high concentrations of Fe3 or CrVI favorite the interactions between fullerols and BSA.
- Physical Chemistry