Accession Number:

ADP011244

Title:

Characteristics of Acoustic Wave Propagation in Dermis for the Diagnosis of the Superficial Tissue Damage in Radiation Therapy

Descriptive Note:

Corporate Author:

NATIONAL YANG-MING UNIV TAIPEI (TAIWAN)

Report Date:

2000-07-01

Pagination or Media Count:

7.0

Abstract:

Measurement of tissue radiation damage quantitatively in radiation therapy is very important to optimize the therapeutic treatment. Ionized radiation induces homogenization of the extracellular matrix which is synthesized by fibroblast and the randoinization of the orientation of the collagen fibers in dermis If the dermis is exposed by ionized radiation, a thermal acoustic shear wave which propagates in dermis becomes harmonic wave Otherwise an inharmonic wave is expected because of inhomogeneous and the arisotropic properties of dermis A polarized optical heterodyne interferometer was setup in order to measure the transverse displacement of the shear wave in order to analyze the propagation mode of the shear wave in dermis. The detection sensitivity of the displacement was lum and the dynamic range was 300 run in this arrangement. The lowest dose that can be detected by the exposure of 4 MeV radiation on porcine dermis was I cGy.

Subject Categories:

  • Medicine and Medical Research
  • Radiobiology
  • Optical Detection and Detectors

Distribution Statement:

APPROVED FOR PUBLIC RELEASE