Gold Standard Tests
SERVICE DE MEDICINE AERONAUTIQUE CLAMART (FRANCE)
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While drug toxicity which targets inteinal, especially excretory, organs is aggressively evaluated in laboratory and clinical trials pilor to marketing, adverse effects on systems of interest to aviation, e.g., the special senses, are only rarely evaluated. It is the intent of this guideline to recommend tests which have been successfully employed in earlier research to detect medication effects. Where that proved impossible, tests were chosen that were known to be sensitive in detecting abnoimalities typically caused by medications e.g., contrast sensitivity function for visual abnor- malities. Also, tests with a history of use in clinical medicine were preterred, since they were more likely to be available, well validated, and familiar to potential investigators, although for some areas such as cognitive testing this was impractical. Since baseline testing should be readily available when investigating drug effects, tests with a higher degree of sensitivity and reproducibility were preferred to those with greater specificity. Note that some tests have been discussed, not necessarily to be recommended. Also, even for those tests that are recommended, we do not mean to imply that all tests be done on all drugs the testing regimen should be tailored to potential areas of concern.