Accession Number:

ADP007173

Title:

An Overview of the affected-Pedigree-Member Method of Linkage Analysis,

Descriptive Note:

Corporate Author:

PITTSBURGH UNIV PA

Personal Author(s):

• Weeks, Daniel E.
• Lange, Kenneth

Report Date:

1992-01-01

Pagination or Media Count:

6.0

Abstract:

Human geneticists have been extremely successful in the past decade in mapping rare disease genes. For common diseases with a substantial genetic component, the payoff for human health is larger, but the mapping problems are harder. There is a need for robust statistical techniques that require minimal assumptions about the mode of inheritance of the disease studied. The affected-pedigree-member APM of linkage analysis makes virtually no assumptions about disease transmission except that it is independent of marker transmission in a pedigree. We discuss here an extension of the APM method from single markers to multiple closely linked markers. This extension should improve the power of the APM method to detect linkage.

Descriptors:

• *DISEASES
• *HEALTH
• GENES
• GENETICS
• HUMANS
• LINKAGES
• MAPPING
• MARKERS
• POWER

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE