Mechanisms of Immune Failure in Burn Injury,
DEFENCE AND CIVIL INST OF ENVIRONMENTAL MEDICINE DOWNSVIEW (ONTARIO)
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The burden on military medical services in handling burn casualties is daunting as all physiological systems will become affected. Severe burns in a battlefield setting have a very low salvage rate, to a great degree because of the immune failure which invariably develops. Evaluations of responses of lymphocytes taken from burn patients over several weeks following the burn 30 TBSA, have revealed that the immune failure which follows thermal injury involves T cell activation events. Interleukin 2, which is normally produced by activated T lymphocytes, is very poorly produced by cells cultivated in vitro taken from non-surviving patients, whereas some production continues, although at below normal levels, in patients who ultimately survive their injury.
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