Accession Number:

ADP006365

Title:

Heterogeneity of Enzyme-Altered Foci in Rat Liver,

Descriptive Note:

Corporate Author:

GERMAN CANCER RESEARCH CENTER HEIDELBERG INST OF BIOCHEMISTRY

Report Date:

1990-07-01

Pagination or Media Count:

24.0

Abstract:

Enzyme-altered foci EAF in liver are assumed to be precursor lesions for tumors in this organ. Results obtained with selected hepatocarcinogens which produce lesions of differing phenotype and growth behavior indicate that not the total number of enzyme-altered cells, but rather, the proliferation of individual cell clones is of major importance for additional changes leading to malignancy. Analyses including multiple marker enzymes demonstrate a relationship between foci phenotype and proliferation. The inducibility of certain down-regulated enzymes in EAF indirectly suggests disturbances in the expression of regulatory genes such as protooncogenes. Data on Ha-ras and c-myc protooncogene expression in EAF are presented.

Subject Categories:

  • Medicine and Medical Research
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE