Accession Number:

ADP006354

Title:

A QSAR Model for the Estimation of Carcinogenicity. Example Application to an Azo Dye,

Descriptive Note:

Corporate Author:

HEALTH DESIGNS INC ROCHESTER NY

Personal Author(s):

Report Date:

1990-07-01

Pagination or Media Count:

15.0

Abstract:

Because carcinogenicity bioassays are time-consuming, costly, and use animal resources, structure-activity relationship SAR equations that model toxicological endpoints have been developed to make alternative methods available which approximate the results that could be obtained from bioassays, but which are less expensive and time-consuming and use fewer, if any, animals. These equations are based on sets of bioassay results and explain the endpoint under consideration in terms of substructural and other parameters that describe the chemical entities. The resulting equations - or models - can then be used to estimate - or predict -the endpoint for new structures. The estimation is followed by validation procedures.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE