Accession Number:

ADP006106

Title:

An approach in determining the effects of psychostimulants on cerebral electrical activity in the non-human primate(Une Approche Des Effets De Psychostimulants Sur L'Activite Electrique Cerebrale Chez Le Primate Non Humain),

Descriptive Note:

Corporate Author:

ADVISORY GROUP FOR AEROSPACE RESEARCH AND DEVELOPMENT NEUILLY-SUR-SEINE (FRAN CE)

Personal Author(s):

Report Date:

1988-02-01

Pagination or Media Count:

11.0

Abstract:

The purpose of this work was to determine the very original properties of this new psychostimulant agent against two other conventional stimulants viz., caffeine and d-amphetamine. The drug d-amphetamine is still given to aircrew in France and, of course, it has well-known side effects. The new drug was studied in our laboratory in the non-human primate, the rhesus monkey. At the dosage indicated -- 25 mgkg -- there were no side effects in the performance of the animal nor in its vegetative parameters viz., in blood pressure and heart rate. The main effect of the drug was that it kept the animal awake, though not as a stimulant. This effect would give the impression that the drug is not comprised of an amphetamine-like type of molecule. Its an action which is quite specific - as based on other studies in apes and rats -- in that is appears to work on post-synaptic brain centres at that level of dosage. Of course, at a higher dosage it would probably have a doping effect. js

Subject Categories:

  • Psychology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE