Pharmacological Approaches to Performance Enhancement in Animals,
TROPONWERKE GMBH AND CO COLOGNE GERMANY (F R)
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Drug effects were studied on learning and working memory performance in young, normal rats, as well as on reactions to hypoxia and stress. While some of the treatments reduced cognitive parameters under normal conditions, none improved them in a meaningful way. However, several substances were found to improve performance disrupted by exposure to hypoxia. These substances included piracetam, nimodipine, and ipsapirone. An additional characteristics of ipsapirone was an amelioration of negative responses to stress. Due to the well-understood mechanisms of action of nimodipine and ipsapirone, their low toxicity, and their lack of negative effects on normal cognitive performance, it is suggested that these drugs could prove to be useful therapeutic agents under conditions of high information processing load.
- Stress Physiology