Accession Number:

ADP005158

Title:

In vitro Methodology for Percutaneous Absorption Studies

Descriptive Note:

Corporate Author:

GENERAL DYNAMICS/ELECTRONICS ROCHESTERNY

Personal Author(s):

Report Date:

1985-05-01

Pagination or Media Count:

8.0

Abstract:

The absorption through the skin of toxic compounds can be significant and must be considered when dermal contact occurs. In vitro methods for measuring percutaneous absorption have been demonstrated to give values in good agreement with in vivo results in human and animal studies. Rates of absorption can be measured more accurately by in vitro techniques since sampling takes place directly below the barrier layer. Procedures are discussed for performing these measurements in the static and flow-through diffusion cell. A method for the determination of the absorption of hydrophobic compounds using in vitro techniques is described.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE