In vitro Methodology for Percutaneous Absorption Studies
GENERAL DYNAMICS/ELECTRONICS ROCHESTERNY
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The absorption through the skin of toxic compounds can be significant and must be considered when dermal contact occurs. In vitro methods for measuring percutaneous absorption have been demonstrated to give values in good agreement with in vivo results in human and animal studies. Rates of absorption can be measured more accurately by in vitro techniques since sampling takes place directly below the barrier layer. Procedures are discussed for performing these measurements in the static and flow-through diffusion cell. A method for the determination of the absorption of hydrophobic compounds using in vitro techniques is described.