Use of Skin of Non-Primate Strains for Determination of Percutaneous Penetration,
LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA DIV OF CUTANEOUS HAZARDS
Pagination or Media Count:
A variety of animals have been evaluated for the ability of their skin to mimic the permeability properties of human skin. To further compare human and pig skin permeability, the in vitro percutaneous penetration of a number of compounds was determined on excised human skin for comparison to in vitro pig skin data. To obtain better agreement between in vitro and in vivo penetration values, the in vitro percutaneous penetration of a range of compounds was determined under conditions where the thickness of the dermis was reduced approximately 50 percent split thickness skin, and radioactivity residues in the dermis were added to the radioactivity recovered from the penetration cell fluid.