Mechanisms of Cell Injury with Hepatotoxic Chemicals
HAHNEMANN UNIV SCHOOL OF MEDICINE PHILADELPHIA PA
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Toxic chemicals can be broadly divided into two classes. The first requires metabolism by the target cells, and the cell killing is dependent on this metabolism. The second group does not require metabolism by the target cells. Compounds that require metabolism can be further subdivided into those that are metabolized by the cytochrome P-450 mixed function oxidases, and those that are not. Much of the work on the mechanisms of action of toxic chemicals has dealt with compounds that are metabolized by mixed function oxidation, and the present discussion will focus principally on the results of these studies. There are three consequences of the metabolism of toxic chemicals by mixed function oxidases that may be responsible for the genesis of membrane alterations that may in turn relate to the genesis of lethal cell injury 1 the formation of free radicals, 2 the formation of electrophilic products, and 3 the generation of activated oxygen species.
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