Accession Number:

ADP005144

Title:

Chemical Carcinogenesis Testing and Related Issues - Subchronic Studies and Related Issues

Descriptive Note:

Corporate Author:

LITTLE (ARTHUR D) INC CAMBRIDGE MA

Personal Author(s):

Report Date:

1985-05-01

Pagination or Media Count:

42.0

Abstract:

The prechronic studies in the context of their use in the carcinogenesis bioassay program of the National Toxicology Program NTP were examined in terms of the general use and design of this type of study as a toxicological tool. The purpose of the subchronic study is to predict the toxic effects which may occur in the animals during the chronic administration of the test agent. Based on the subchronic observations, a predicted is made of the maximum tolerated dose MTD that can be given to the animals in the chronic study without producing unwanted side effects.

Subject Categories:

  • Toxicology
  • Genetic Engineering and Molecular Biology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE