Chemical Carcinogenesis Testing and Related Issues - Subchronic Studies and Related Issues
LITTLE (ARTHUR D) INC CAMBRIDGE MA
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The prechronic studies in the context of their use in the carcinogenesis bioassay program of the National Toxicology Program NTP were examined in terms of the general use and design of this type of study as a toxicological tool. The purpose of the subchronic study is to predict the toxic effects which may occur in the animals during the chronic administration of the test agent. Based on the subchronic observations, a predicted is made of the maximum tolerated dose MTD that can be given to the animals in the chronic study without producing unwanted side effects.
- Genetic Engineering and Molecular Biology