Effects of Age on Reactions to Ozone: Morphological Effects of Acute Exposure,
CALIFORNIA UNIV DAVIS
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Since most ozone toxicology studies use healthy young adult male animals, there is little information concerning the relative sensitivity of animals of other ages to the physiological, biochemical, or morphological effects of ozone. Because different biological processes are occurring in the lungs of some of these subpopulations, e.g. lung growth and development in infants and juveniles but loss of function in aged, there is reason to question whether mechanisms or magnitude of effects of ozone inhalation can be directly extrapolated from studies of healthy young adult males to these other subpopulations. Most studies indicate that neonatal rats are resistant to the effects of ozone until weaning and that sensitivity to oxidant air pollutants increases with age. This study compares morphologic effects in lungs from young rats exposed soon after becoming sensitive to ozone with those in adult rats near their maximum body size.