Accession Number:

ADP005139

Title:

Chemical Interactions in Complex Atmospheres and the Effect on Uptake of Individual Components by the Lung

Descriptive Note:

Corporate Author:

CALIFORNIA UNIV IRVINE DEPT OF COMMUNITY AND ENVIRONMENTAL MEDICINE

Personal Author(s):

Report Date:

1985-05-01

Pagination or Media Count:

11.0

Abstract:

The fraction of an inhaled toxic compound which penetrates the upper airways to the lung parenchyma will constitute the biologically effective dose this dose can be altered by several phenomena. The principles involved have been reasonably well documented for particulate matter and for individual gases and vapors. Relatively complex gas, vapor, and particle mixtures are, however, more difficult to characterize. Among the likely processes which might alter the magnitude or site of deposition are the alteration of particle size, changes in the aerodynamic properties of the airways themselves, adsorptive phenomena that allow otherwise easily removed gases or vapors to penetrate more deeply within the respiratory tract, and the formation of new, labile but potent toxic agents.

Subject Categories:

  • Stress Physiology
  • Air Pollution and Control

Distribution Statement:

APPROVED FOR PUBLIC RELEASE