Accession Number:

ADP004423

Title:

The Effect of Injury on Fibronectin,

Descriptive Note:

Corporate Author:

ALBANY MEDICAL COLL NY

Personal Author(s):

Report Date:

1983-01-21

Pagination or Media Count:

5.0

Abstract:

Fibronectin fibre fiber nectere to link or bind is a large molecular weight glycoprotein in that has both opsonic and adhesive biologic functions. A soluble form of fibronectin is found in blood, lymph, and other tissue fluids, while an insoluble form is found in blood, lymph and other tissue fluids, while an insoluble form is found in connective tissues and associated with basement membranes. Fibronectin has domains with high affinity for collagen, gelatin, fibrin, actin, Staph, aureus and heparin. It opsonizes denatured collagen-coated particles, cytoskeletal debris, fibrin-fibrinogen complexes and other nonbacterial particulates and augments their phagocytic removal. Plasma fibronectin deficiency and reticuloendothelial dysfunction is observed in critically ill septic surgical, trauma or burn patients with multiple organ failure.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE