Monitoring of Lymphocyte Function,
CALIFORNIA UNIV SAN FRANCISCO
Pagination or Media Count:
It is now well established that severe thermal injury depresses a number of host defense systems. These post-burn alterations affect both the nonspecific inflammatory systems i.e., complement, phagocytic and the specific immune systems lymphocytes, monocytes. Lymphocyte function is imporatant not only in specific host defense systems but also in nonspecific inflammatory systems. Lymphocytes produce antibody, act as cytotoxic killer cells, and regulate cellular responses. In addition, they also produce a number of lymphokines which indirectly influence phagocytosis, neutrophil chemotaxis and granulocyte maturation. Lymphokines mediate these activities by their direct action on the protein synthesis functions of the macrophagemonocyte M0 population. The M0 population through its production of prostaglandins, fibrinonectin, complement components, leukocyte chemotactic factor, and colony stimulating factor regulate polymorphonucleocyte PMN maturation, migration from bone marrow, chemotactic response and phagocytic capacity, as well as modulating immune function. Lymphokines can modulate the production of all of these M0 products, as well as directly act as chemotactic agents in some cases. Monitoring lymphocyte function can therefore provide a good indication of total host defensive capacity.