Bacterial Resistance to Topical Agents,
ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX
Pagination or Media Count:
Sulfonamide resistance was greater than 78 in gram-negative organisms isolated during the last 12 months. This is a continuation of our previous experience. Sulfadiazine SD in silver-sulfadiazine AgSD is the only bacteriologically active sulfonamide used on our burn ward. We investigated the requirement of sulfadiazine for the in vitro activity of silver-sulfadiazine. A bacteriologically inactive analog of sulfadiazine was synthesized. The structure of sodium salts of sulfadiazine and the synthesized analog benzenesulfonamidopyrimidine ISR-44 are presented in Figure 1. As can be seen, the two structures are very similar except that the analog does not have the N-4 amino group para-amino necessary for paraminobenzoic acid antagonism. The silver salts of sulfadiazine and its analog were prepared. The two sodium salts and the two silver salts were then examined for in vitro and in vivo burned rat activity.