Pharmacologic Intervention in Shock,
YALE UNIV NEW HAVEN CONN DEPT OF SURGERY
Pagination or Media Count:
A scheme of the progressive changes that occur with shock and ischemia which we have previously discussed in detail is presented in Figure 1. The major changes during such conditions are in microcirculation, cell membrane transport and function, energy metabolism and mitochondrial function. These progressive and interrelated events eventually lead to cell swelling. Studies showed that infusion of ATP-MgCl2 along with volume restitution following hemorrhagic shock and sepsis-peritonitis in animals proved beneficial for survival.