Accession Number:

ADP004406

Title:

Effect of Injury or Resuscitation on Coagulation Mechanisms,

Descriptive Note:

Corporate Author:

UNIVERSITY OF SOUTH ALABAMA MOBILE COLL OF MEDICINE

Personal Author(s):

Report Date:

1983-01-21

Pagination or Media Count:

4.0

Abstract:

In order to determine if products of fibrinolysis alter filtration or permeability, exogenous purified Fragments D and E products, and plasmin were tested in an isolated, autoperfused catileum preparation. Steady-state lymphatic and plasma protein concentration ratio C sub LC sub P and lymph flows Q sub L were measured at a venous outflow pressure of 0 mmHg. Data was analyzed for each animal group by the paired Student test for Q sub L, C sub LC sub P, and protein clearance Q sub L x C sub LC sub P. In cats which received Fragment D n7, Q sub L and clearance increased five-fold P 0.002, but C sub LC sub P was not altered, which suggests a permeability change. Ileal mucosa wa depithelialized and blood vessels were damaged. Fragment E n7 provoked a slight increase in Q sub L P0.01, but not in C sub LP E sub L or clearance. Histology was normal.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE