Pharmacokinetic Interactions of Mixtures,
AIR FORCE AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OH
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This paper is divided into two sections. First, we describe several examples from the literature which indicate toxicologic or pharmacokinetic interactions arising during co-exposure to two vapors. Secondly, we discuss the metabolic basis of these interactions and try to generalize these results to illuminate the interactions that are expected during exposure to more complex mixtures. When possible, the examples in the second portion are given a quantitative basis by applying a physiological pharmacokinetic model to describe these interactions.