Accession Number:

ADP004025

Title:

Electrophysiologic Changes in Organophosphorus-Induced Delayed Neurotoxicity,

Descriptive Note:

Corporate Author:

WARNER-LAMBERT/PARKE-DAVIS ANN ARBOR MI

Personal Author(s):

Report Date:

1984-08-01

Pagination or Media Count:

9.0

Abstract:

There is now a considerable body of literature showing that organophosphorus OP agents which produce organophosphorus-induced delayed neuropathy OPIDN also inhibit neurotoxic esterase NTE. Although the functional relationship of these two events has not been established, the correlation is strong enough that NTE inhibition can be used as a reliable predictor of the peripheral neuropathy potency of a given agent Johnson, 1975. There is a wealth of data describing the histopathology and biochemistry associated with OPIDN, but few electrophysiologic correlates have been made.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE