Pathology of Organophosphorus-Induced Delayed Neurotoxicity,
VIRGINIA-MARYLAND REGIONAL COLL OF VETERINARY MEDICINE BLACKSBURG VA
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Details of the nature and metabolic effects of the neurotoxic organophosphorus compounds, experimental protocols used, species susceptibility, and clinical disease produced in studies of delayed neuropathy are considered elsewhere in these proceedings. This presentation will emphasize the nature of associated nervous system lesions. To properly appreciate this, a brief note of clinical abnormalities is useful. Administration of an appropriate dose of a neurotoxic organophosphorus compound to a susceptible species produces clinical signs in about 1-3 weeks. In hens given tri-ortho-tolyl or cresyl phosphate TOTP, an unsteady, clumsy gait began in about 8-10 days, and in association with ataxia, progressed to weakness and paralysis. Wings were affected later, and to a lesser degree.