Chemistry and Metabolism of Delayed Neurotoxic Organophosphorus Esters,
AMERICAN CYANAMID CO PRINCETON NJ AGRICULTURE RESEARCH DIV
Pagination or Media Count:
In general, correlations between organophosphorus ester-induced delayed neurotoxicity OPIDN in vivo and physicalchemical parameters or inhibition of NTE in vitro have not been totally satisfactory. Some correlations of OPIDN with leaving groups, length of O-alkyl chains, or the nature of the P-C group have been demonstrated, but such correlations only apply to closely related series of compounds where two of the substituents remain constant while the third is varied. Although the biochemical and physiologic functions of NTE are unknown, there are numerous satisfactory correlations between inhibitors of NTE in vitro and OPIDN in vivo. However, significant exceptions have been found which at present make it impossible to predict those structures most likely to produce OPIDN.