Molecular Mechanisms of n-Hexane Neurotoxicity,
NEW YORK STATE DEPT OF HEALTH ALBANY
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A hypothetical molecular mechanism of action must ideally account for the structureactivity relationships, neurofilament accumulation, in vivo covalent protein binding, direct action on axonal components, and target organ specificity which are characteristic of the neuropathy caused by these compounds. Although this ideal has not yet been realized, substantial progress has been made toward elucidation of the crucial events leading to neuropathy. Ultimate success awaits exploration of the molecular interaction of the neurotoxic diketones with axonal components in vivo. The distinguishing features of n-hexane neuropathy are listed.