Interactions of Ketones and Hexacarbons,
ALBERT EINSTEIN COLL OF MEDICINE BRONX NY
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Methyl ethyl ketone appears to accelerate the onset and severity of the dying-back neuropathy produced by hexacarbons. The mechanism underlying this potentiation is unknown. It was our intention to replicate and investigate this interaction in tissue culture using organotypic explants of mouse spinal cord with attached dorsal root ganglia and striated muscle. At maturity, this complex displays morphological and bioelectrical features typical of mammalian neuromuscular tissues in vivo. This type of tissue culture has been used for many years in experimental neurobiology and neuropathology and is amenable to neurotoxicological inquiries. It has been especially valuable in addressing the pathogenic and metabolic events of subchronic exposure to aliphatic hexacarbons.