Pharmacologic Management of Sepsis,
UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD
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The pharmacological management of sepsis remains controversial. Most of the drugs utilized clinically treat the symptoms of the disease, and are not necessarily directed at fundamental mechanisms that are known to be present in sepsis. A broad data base is emerging, indicating that NSAID should be used in human clinical trials. Prostaglandins are sensitive indicators of cellular injury and may be a mediator for a number of vasoactive chemicals. Opiate antagonists and calcium channel blockers require more in-depth data however, recent studies generate excitement for their potential use in the critically ill patient. Pharmacologic effects of antibiotics, in concert with other drugs, suggest an entirely new approach to the pharmacologic treatment in sepsis. There is no doubt that new treatment modalities or adjunctive therapies must be utilized to alter the poor prognosis of severe sepsis that we have observed in the past 4 decades.