Colonization Abnormalities as a Major cause of Trauma-Induced Infections,
NAVAL MEDICAL RESEARCH INST BETHESDA MD
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In recent years, another facet of host-microbial interactions has received increasing attention. This facet concerns the phenomenon of abnormal colonization of mucosal surfaces by microorganisms. Abnormal colonization and defense suppression are two key events for the establishment of opportunistic infections following direct and mediated effects of severe injury. This report will describe mechanisms influencing the colonization of mucosal surfaces by microorganisms, show how this process may be altered by trauma, and propose some means by which colonization may be manipulated for the benefit of the patient.