Acute-Phase Proteins and Systemic Immunity,
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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Studies on acute-phase protein changes in various types of trauma are reviewed and the possible immunological implications of these changes are discussed. The studies from our laboratories described correlations of the serum levels of certain acute-phase proteins with several clinically relevant aspects of the host-disease relationship in cancer. Specifically, the proteins correlated with a primary delayed cutaneous hypersensitivity to DNCB, b in vitro lymphocyte reactivity to PHA and total T-cell levels, c tumor clinical stage and patient course after treatment, and d efficacy of experimental therapy regimens, in comparison with other indices of efficacy such as T-cell levels of patient survival. Since the correlations made with the proteins selected for the studies may not be obtained with other acute-phase proteins, it appeared appropriate and helpful to select a term Immune-Reactive Proteins to denote these and other proteins found to show similar properties in future investigations. It appears that the correlations emphasize the importance of evaluations of systemic immunity, compared to cellular immune parameters, for gaining insight into clinically relevant aspects of host-disease relationships.