Canine Hematopoiesis in a Model of Combined Injury
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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The development of a large animal model for CI within the context of a nuclear disaster required that we describe, experimentally, the essential features of the radiobiology of acute effects in the canine. The large-animal model is also appropriate for assessing the immunologic, pharmacologic, and surgical modes of intervention of following CI. The canine model of CI at the AFRRI has stressed three developmental aspects a establishing the radiobiology of the canine hemopoietic system, b choosing a relevant model for peritoneal sepsis, and c identifying several choices for physical trauma. This paper stresses the relevance of the first aspect, the radiation-induced suppression and recovery of the hemopoietic system.
- Anatomy and Physiology