The Role of the Macrophage in the Host Response to Bacterial Endotoxins
SCRIPPS CLINIC AND RESEARCH FOUNDATION LA JOLLA CA
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Unique to Gram-negative bacilli is the presence of a complex glycolipid in the outer cell membrane. This component, termed endotoxin or lipopolysaccharide LPS, is now generally recognized as the bacterial product that is responsible for initiating the biochemical changes leading to shock, DIC, and death. The purpose of this report is to describe a number of mediators produced by LPS-treated macrophages that may participate in the host response to LPS, namely, a supernatant factor of LPS-treated macrophage M, which suppresses adrenocortical steroidogenesis, and a membrane-bound procoagulant activity, which activates coagulation Factor X directly.
- Anatomy and Physiology